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Functional characterization of SARS-CoV-2-specific T and B cell long-lasting Immunity in immunocompetent and immunosuppressed patients developing SARS-CoV-2 infection (COV-Immunity)

Description: in this project we will investigate, using highly sensitive immune assays, the development of short and long-lasting immunity, both humoral and cellular, specific against SARS-CoV-2, at the time of infection and at different time points afterwards up to 24 months in previously healthy individuals, patients with relevant co-morbidities, solid organ transplant patients receiving chronic immunosuppression and patients with malignancies receiving chemotherapy.

  • Centre: Instituto de Investigación Biomédica de Bellvitge (IDIBELL).
  • IPs: Oriol Bestard Matamoros.
  • Budget: 207,714.35 €.
  • ISCIII’s reference: COV20/00324.

More information: the main purpose of our project is to precisely characterise the advent of adaptative immunity memory responses against the SARS-CoV-2 virus as well as understanding if SARS-CoV-2 leads to long-term immunity in different patient population. The result of our study will have a major clinical impact on Public Health Medicine since the knowledge of the degree and quality of adaptative immunity against SARS-CoV-2 will allow identifying patients at risk of re-infection thus, enabling guided preventive strategies in a personalised manner.

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