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Study of the Microbiome and Virome associated with COVID-19

Description: Infection with SARS-CoV-2 virus ranges from asymptomatic forms to very severe bilateral pneumonias that often result in the death of the patient. Microbiome and virome are altered in a large number of pathologies, but their involvement in this process is unknown, although it is possible that both are involved in the different clinical severity of the patient. Therefore, the study of the microbiome and the virome should be carried out by means of a bioinformatic and statistical analysis of the microbial diversity and the taxa present in each of the samples, in order to identify biomarkers of severity of the process that can be used in the best management of the patient.

  • Centre: Instituto de Investigación Sanitaria y Biomédica de Alicante.
  • IPs: Juan Carlos Rodríguez Díaz.
  • Budget: 168,050.00 €.
  • ISCIII’s reference: COV20/00236.

More information: The main objective of the project is to study the microbiome and viroma associated with the disease CoVid19 in order to determine its importance in the development of the process, and thus generate a system with which to detect early the severity of the patient. The samples processed for the detection of the SARS-CoV-2 virus in the province of Alicante. This project is included within 2 of the priority research lines established by the ISCIII:
– Clinical, biological and molecular characterization of the disease, in this sense we will study the clinicopathological and own characteristics of the microbiome and viroma of the included patients in the study in order to detect prognostic biomarkers of infection severity.
– Study of environmental and social factors of the spread, risk factors, the approach This line will be carried out through the comparative study of the microbiome and the viroma, which They may be related to a greater predisposition to contagion or the development of the disease. The identification of bacteria or viruses that contribute to the aggravation of the disease can open new possibilities in the rapid diagnosis and treatment of these patients. Currently the research group is already cryopreserving samples to perform both objectives.

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